Prophet Mohammad had five children from his first wife Khadijah. One son, Al qasim died when he was still a baby, and four daughters: Zaynab, Ruqayah, Fatimah, and Om Kolthoom. The last child, a boy Abrahim was born 628 A.D. He was the only child born to the Prophet after Prophet Mohammad (pbuh) knew that he was to be a Messenger of God. His mother was Maria, an Egyptian whom the king of Egypt sent to Prophet Mohammad (pbuh) as a handmaid servant and Prophet Mohammad married her in 627.
Zaynab married her cousin Al'Ass Ibn Al-Rabeah. Zaynab had only one child who died as a baby. Zaynab died in 630 A.D.
Ruqayah was the wife of Othman Ibn affan. She had one boy who died possibly from an infection after a rooster pecked his eye. She died in 624 A.D. She died on the same day of the battle of Badr.
Om Kolthoom was also married to Othman after Ruqayah's death . She had no children. She died in 631 A.D.
Fatimah married Ali Ibn Aby Talib who was the cousin of the Prophet (pbuh) and who later became the fourth Calipha. He died in 662 A.D. They had two sons, Al-Hassan and Al-Hussein and one daughter Om Kolthoom. Fatimah died in 632 A.D.
Al-Hassan was seven years old, and Al-Huseein was six when Prophet Mohammad (pbuh) died in 632 A.D. The Prophet loved them very much. There were even some prophecies about them. Al-Hassan became Calipha in 662 A.D. He resigned after five months and passed his leadership to Mouawiah Ibn Aby Sofian. Prophet Mohammad Prophesied that a man named Mohammad Ibn Abdullah (Al Mahdy), a descendant of Al Hassan, would one day work the Prophet Jesus (pbuh) to kill the Anti-Christ and establish an Islamic state. Al-Hussein died in 682 A.D.
Most of Al-Hussein's children were killed in the wars. Only two children survived after Al-Hussein's death. The daughter of Fatimah, Om Kolthoom married Omar Ibn Al Khataab, the second Calipha. She had a boy named Zayd. Zayd fought along with his uncle Al-Hussein, in the battle of Karbellah. The descendants of Al-Hussein and Zayd still exist today. Fatimah died a few months after the death of Prophet Mohammad (pbuh). The Prophet prophesied that Fatimah would be the first of his family to die after him, and it would be soon.